Maternal thyroid autoimmunity during pregnancy and the risk of attention deficit/hyperactivity problems in children: The generation r study Academic Article uri icon


MeSH Major

  • Attention Deficit and Disruptive Behavior Disorders
  • Autoimmunity
  • Prenatal Exposure Delayed Effects
  • Thyroid Diseases


  • Our findings imply that the elevated titers of TPOAbs during pregnancy impact children's risk of problem behavior, in particular, attention deficit/hyperactivity. The observed effect is only partially explained by maternal TSH levels. These findings may point to a specific mechanism of Attention Deficit/Hyperactivity Disorder in children. Nevertheless, we can only speculate about public health implication of the study, as there is no specific treatment for TPOAb-positive pregnant women with normal thyroid function. Further investigation is needed to explore whether TPOAb-positive pregnant women and their children can benefit from close monitoring and early detection of developmental delay in populations at risk.

publication date

  • February 2012



  • Academic Article



  • eng

PubMed Central ID

  • PMC3271370

Digital Object Identifier (DOI)

  • 10.1089/thy.2011.0318

PubMed ID

  • 22175242

Additional Document Info

start page

  • 178

end page

  • 86


  • 22


  • 2