An unsuspected property of natriuretic peptides: Promotion of calcium-dependent catecholamine release via protein kinase g-mediated phosphodiesterase type 3 inhibition Academic Article uri icon

Overview

MeSH Major

  • Catecholamines
  • Cyclic GMP-Dependent Protein Kinases
  • Natriuretic Peptide, Brain
  • Natriuretic Peptides
  • Phosphodiesterase 3 Inhibitors

abstract

  • Our results show that natriuretic peptides, at concentrations likely to be reached at cardiac sympathetic nerve endings in advanced congestive heart failure, promote norepinephrine release via a protein kinase G-induced inhibition of phosphodiesterase type 3-mediated cAMP hydrolysis. We propose that this proadrenergic action may counteract the beneficial cardiac and hemodynamic effects of natriuretic peptides and thus explain the ineffectiveness of nesiritide as a cardiac failure medication.

publication date

  • January 17, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3287346

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.111.059097

PubMed ID

  • 22158783

Additional Document Info

start page

  • 298

end page

  • 307

volume

  • 125

number

  • 2