Plasmodium falciparum STEVOR proteins impact erythrocyte mechanical properties. Academic Article uri icon

Overview

MeSH

  • Cells, Cultured
  • Fluorescent Antibody Technique, Indirect
  • Humans
  • RNA, Messenger
  • Real-Time Polymerase Chain Reaction

MeSH Major

  • Antigens, Protozoan
  • Erythrocyte Membrane
  • Erythrocytes
  • Malaria, Falciparum
  • Plasmodium falciparum

abstract

  • Infection of erythrocytes with the human malaria parasite, Plasmodium falciparum, results in dramatic changes to the host cell structure and morphology. The predicted functional localization of the STEVOR proteins at the erythrocyte surface suggests that they may be involved in parasite-induced modifications of the erythrocyte membrane during parasite development. To address the biologic function of STEVOR proteins, we subjected a panel of stevor transgenic parasites and wild-type clonal lines exhibiting different expression levels for stevor genes to functional assays exploring parasite-induced modifications of the erythrocyte membrane. Using this approach, we show that stevor expression impacts deformability of the erythrocyte membrane. This process may facilitate parasite sequestration in deep tissue vasculature.

publication date

  • January 12, 2012

has subject area

  • Antigens, Protozoan
  • Cells, Cultured
  • Erythrocyte Membrane
  • Erythrocytes
  • Fluorescent Antibody Technique, Indirect
  • Humans
  • Malaria, Falciparum
  • Plasmodium falciparum
  • RNA, Messenger
  • Real-Time Polymerase Chain Reaction

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3257022

Digital Object Identifier (DOI)

  • 10.1182/blood-2011-08-370734

PubMed ID

  • 22106347

Additional Document Info

start page

  • e1

end page

  • e8

volume

  • 119

number

  • 2