Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array Academic Article uri icon

Overview

MeSH Major

  • CpG Islands
  • DNA Methylation
  • Gene Dosage
  • Leukemia
  • Lymphoma
  • Oligonucleotide Array Sequence Analysis

abstract

  • Changes in DNA copy number (CN) and DNA methylation represent important aberrations for lymphomas and other cancers. Here, for the first time, we show that the Illumina Infinium Methylation (IIM) assay, although not originally designed for CN profiling, is able to estimate CN changes. We compared the IIM CN profiles to those obtained with a standard technique in a series of diffuse large B-cell lymphomas: the profiles showed a high degree of consensus. The demonstration of CN profiling as an additional function of the IIM assay may impact the choice of platform for methylation profiling of haematological and solid tumours.

publication date

  • February 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2141.2011.08946.x

PubMed ID

  • 22118580

Additional Document Info

start page

  • 354

end page

  • 7

volume

  • 156

number

  • 3