Familial aggregation of acute myeloid leukemia and myelodysplastic syndromes Academic Article uri icon

Overview

MeSH Major

  • Leukemia, Myeloid, Acute
  • Myelodysplastic Syndromes

abstract

  • We did not find evidence for familial aggregation of the severe end of the spectrum of myeloid malignancies (AML and MDS). The risks of myeloproliferative neoplasms were modestly increased with trends toward significance, suggesting a possible role of inheritance. In contrast, although limited in sample size, relatives of young patients with AML were at increased risk of AML/MDS, suggesting that germline genes may play a stronger role in these patients. The increased risk of all hematologic malignancies and of solid tumors among relatives of patients with AML suggests that genes for malignancy in general and/or other environmental factors may be shared.

publication date

  • January 10, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3255562

Digital Object Identifier (DOI)

  • 10.1200/JCO.2011.37.1203

PubMed ID

  • 22162584

Additional Document Info

start page

  • 179

end page

  • 83

volume

  • 30

number

  • 2