Prevalence of BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breast and pancreatic cancer
Academic Article
Overview
MeSH Major
Breast Neoplasms
Genes, BRCA1
Genes, BRCA2
Germ-Line Mutation
Jews
Pancreatic Neoplasms
abstract
BRCA1 and BRCA2 mutations are observed with nearly equal distribution in AJ breast-pancreas cancer families, suggesting that both genes are associated with PC risk. In this population, a FH of PC was found to have a limited effect on mutation prevalence.
