Assessing the incremental value of diagnostic and prognostic markers: A review and illustration Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Models, Statistical
  • Neoplasms, Germ Cell and Embryonal
  • Testicular Neoplasms

abstract

  • The improvement in standard discrimination measures, which focus on finding variables that might be promising across all decision thresholds, may not detect the most informative markers at a specific threshold of particular clinical relevance. When a marker is intended to support decision-making, calculation of the improvement in a decision-analytic measure, such as NB, is preferable over an overall judgment as obtained from the AUC in ROC analysis.

publication date

  • February 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3587963

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2362.2011.02562.x

PubMed ID

  • 21726217

Additional Document Info

start page

  • 216

end page

  • 28

volume

  • 42

number

  • 2