Structural correlates of selectivity and inactivation in potassium channels Review uri icon

Overview

MeSH Major

  • Potassium Channels

abstract

  • Potassium channels are involved in a tremendously diverse range of physiological applications requiring distinctly different functional properties. Not surprisingly, the amino acid sequences for these proteins are diverse as well, except for the region that has been ordained the "selectivity filter". The goal of this review is to examine our current understanding of the role of the selectivity filter and regions adjacent to it in specifying selectivity as well as its role in gating/inactivation and possible mechanisms by which these processes are coupled. Our working hypothesis is that an amino acid network behind the filter modulates selectivity in channels with the same signature sequence while at the same time affecting channel inactivation properties. This article is part of a Special Issue entitled: Membrane protein structure and function.

publication date

  • February 2012

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3253935

Digital Object Identifier (DOI)

  • 10.1016/j.bbamem.2011.09.007

PubMed ID

  • 21958666

Additional Document Info

start page

  • 272

end page

  • 85

volume

  • 1818

number

  • 2