Delivery of a liposomal c-raf-1 antisense oligonucleotide by weekly bolus dosing in patients with advanced solid tumors: A phase I study Academic Article uri icon

Overview

MeSH Major

  • Genetic Therapy
  • Liposomes
  • Neoplasms
  • Oligonucleotides, Antisense
  • Proto-Oncogene Proteins c-raf

abstract

  • Dose-independent hypersensitivity reactions and dose-dependent thrombocytopenia limited tolerance of LErafAON. Future clinical evaluation of this approach will depend on modification of the liposome composition.

publication date

  • November 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-04-0642

PubMed ID

  • 15534098

Additional Document Info

start page

  • 7244

end page

  • 51

volume

  • 10

number

  • 21