Early-onset colorectal cancer is an easy and effective tool to identify retrospectively Lynch syndrome Academic Article uri icon

Overview

MeSH Major

  • Colorectal Neoplasms
  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • DNA Mismatch Repair
  • Microsatellite Instability

abstract

  • Early age of onset is an effective method to identify retrospectively Lynch syndrome. Taking into account the location and histology features of the tumor, and the familial history of the cases, we notably increase the a priori probability of detecting a germline MMR mutation.

publication date

  • November 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1245/s10434-011-1782-4

PubMed ID

  • 21590452

Additional Document Info

start page

  • 3285

end page

  • 91

volume

  • 18

number

  • 12