Early-onset colorectal cancer is an easy and effective tool to identify retrospectively Lynch syndrome
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Mismatch Repair
Early age of onset is an effective method to identify retrospectively Lynch syndrome. Taking into account the location and histology features of the tumor, and the familial history of the cases, we notably increase the a priori probability of detecting a germline MMR mutation.