Adipose-derived stem cells promote lymphangiogenesis in response to VEGF-C stimulation or TGF-Β1 inhibition Academic Article uri icon

Overview

MeSH Major

  • Adipocytes
  • Lymphangiogenesis
  • Stem Cells
  • Transforming Growth Factor beta1
  • Vascular Endothelial Growth Factor C

abstract

  • Short-term stimulation of ASCs with VEGF-C results in increased expression of VEGF-A, VEGF-C and Prox-1 in vitro and is associated with a marked increase lymphangiogenic response after in vivo implantation. This lymphangiogenic response is significantly potentiated by blocking TGF-β1 function. Furthermore, stimulation of ASCs with VEGF-C markedly increases cellular proliferation and cellular survival after in vivo implantation and stimulated cells express podoplanin, a lymphangiogenic cell marker.

publication date

  • December 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3263831

Digital Object Identifier (DOI)

  • 10.2217/fon.11.121

PubMed ID

  • 22112321

Additional Document Info

start page

  • 1457

end page

  • 73

volume

  • 7

number

  • 12