Adipose-derived stem cells promote lymphangiogenesis in response to VEGF-C stimulation or TGF-Β1 inhibition
Transforming Growth Factor beta1
Vascular Endothelial Growth Factor C
Short-term stimulation of ASCs with VEGF-C results in increased expression of VEGF-A, VEGF-C and Prox-1 in vitro and is associated with a marked increase lymphangiogenic response after in vivo implantation. This lymphangiogenic response is significantly potentiated by blocking TGF-β1 function. Furthermore, stimulation of ASCs with VEGF-C markedly increases cellular proliferation and cellular survival after in vivo implantation and stimulated cells express podoplanin, a lymphangiogenic cell marker.