Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors Academic Article uri icon

Overview

MeSH Major

  • Body Patterning
  • Cerebellum
  • Gene Expression Regulation, Developmental
  • Neurogenesis
  • Repressor Proteins

abstract

  • The design, synthesis and biological evaluation of new analogs of the naturally occurring compound cyclopamine, a Hedgehog signaling inhibitor, are described. Stucture-activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-cancer chemotherapeutic agents.

publication date

  • December 30, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3244726

Digital Object Identifier (DOI)

  • 10.1016/j.tet.2011.10.028

PubMed ID

  • 22199406

Additional Document Info

start page

  • 10261

end page

  • 10266

volume

  • 67

number

  • 52