PHGDH amplification and altered glucose metabolism in human melanoma Article uri icon

Overview

MeSH Major

  • Gene Amplification
  • Glucose
  • Melanoma
  • Phosphoglycerate Dehydrogenase
  • Skin Neoplasms

abstract

  • The metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare. However, an enzyme involved in the de novo synthesis of serine, 3-phosphoglycerate dehydrogenase (PHGDH), was recently identified as a putative oncogene. The potential mechanisms by which PHGDH promotes cancer are discussed.

publication date

  • December 2011

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1111/j.1755-148X.2011.00919.x

Additional Document Info

start page

  • 1112

end page

  • 5

volume

  • 24

number

  • 6