Co-ordination of Incoming and Outgoing Traffic in Antigen-Presenting Cells by Pattern Recognition Receptors and T Cells Review uri icon

Overview

MeSH Major

  • Antigen-Presenting Cells
  • Receptors, Pattern Recognition
  • T-Lymphocytes

abstract

  • Dendritic cells are innate sentinels of the immune system and potent activators of naÏve T cells. Mechanisms must exist to enable these cells to achieve maximal activation of T cells specific for microbial antigens, while avoiding activation of T cells specific for self-antigens. Here we discuss how a combination of signals from pattern recognition receptors and T cells co-ordinates subcellular trafficking of antigen with both major histocompatibility complex class I and class II molecules and T-cell costimulatory molecules, resulting in the preferential presentation of microbial peptides within a stimulatory context.

publication date

  • December 2011

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0854.2011.01251.x

PubMed ID

  • 21762455

Additional Document Info

start page

  • 1669

end page

  • 76

volume

  • 12

number

  • 12