Selective repression of Notch pathway target gene transcription Review uri icon

Overview

MeSH Major

  • Receptors, Notch

abstract

  • The Notch signaling pathway regulates metazoan development, in part, by directly controlling the transcription of target genes. For a given cellular context, however, only subsets of the known target genes are transcribed when the pathway is activated. Thus, there are context-dependent mechanisms that selectively maintain repression of target gene transcription when the Notch pathway is activated. This review focuses on molecular mechanisms that have been recently reported to mediate selective repression of Notch pathway target gene transcription. These mechanisms are essential for generating the complex spatial and temporal expression patterns of Notch target genes during development.

publication date

  • December 2011

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.ydbio.2011.09.018

PubMed ID

  • 21963536

Additional Document Info

start page

  • 123

end page

  • 31

volume

  • 360

number

  • 1