Autophagy: a core cellular process with emerging links to pulmonary disease. Review uri icon

Overview

MeSH

  • Cystic Fibrosis
  • Humans
  • Lung
  • Pulmonary Disease, Chronic Obstructive
  • Tuberculosis

MeSH Major

  • Autophagy
  • Lung Diseases

abstract

  • Autophagy is a highly conserved homeostatic pathway by which cells transport damaged proteins and organelles to lysosomes for degradation. Dysregulation of autophagy contributes to the pathogenesis of clinically important disorders in a variety of organ systems but, until recently, little was known about its relationship to diseases of the lung. However, there is now growing evidence at the basic research level that autophagy is linked to the pathogenesis of important pulmonary disorders such as chronic obstructive pulmonary disease, cystic fibrosis, and tuberculosis. In this review, we provide an introduction to the field of autophagy research geared to clinical and research pulmonologists. We focus on the best-studied autophagic mechanism, macroautophagy, and summarize studies that link the regulation of this pathway to pulmonary disease. Last, we offer our perspective on how a better understanding of macroautophagy might be used for designing novel therapies for pulmonary disorders.

publication date

  • December 1, 2011

has subject area

  • Autophagy
  • Cystic Fibrosis
  • Humans
  • Lung
  • Lung Diseases
  • Pulmonary Disease, Chronic Obstructive
  • Tuberculosis

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3262043

Digital Object Identifier (DOI)

  • 10.1164/rccm.201106-0966CI

PubMed ID

  • 21836133

Additional Document Info

start page

  • 1237

end page

  • 1246

volume

  • 184

number

  • 11