Recommendations for follow-up care of individuals with an inherited predisposition to cancer: I. Hereditary nonpolyposis colon cancer Conference Paper uri icon


MeSH Major

  • Adenosine Triphosphatases
  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • DNA Repair Enzymes
  • DNA-Binding Proteins


  • Efficacy of cancer surveillance or other measures to reduce risk in individuals who carry cancer-predisposing mutations is unknown. Based on observational studies, colonoscopy every 1 to 3 years starting at age 25 years is recommended for individuals known to have HNPCC-associated mutations. Endometrial cancer screening is also recommended, based on expert opinion concerning presumptive benefit. No recommendation is made for or against prophylactic surgery (ie, colectomy, hysterectomy); these surgeries are an option for mutation carriers, but evidence of benefit is lacking. It is recommended that individuals considering genetic testing be counseled regarding the unknown efficacy of measures to reduce risk and that care for individuals with cancer-predisposing mutations be provided whenever possible within the context of research protocols designed to evaluate clinical outcomes.

publication date

  • March 19, 1997



  • Conference Paper



  • eng

PubMed ID

  • 9062331

Additional Document Info

start page

  • 915

end page

  • 9


  • 277


  • 11