Single molecule methods for monitoring changes in bilayer elastic properties Academic Article uri icon

Overview

MeSH Major

  • Lipid Bilayers
  • Patch-Clamp Techniques

abstract

  • Membrane protein function is regulated by the cell membrane lipid composition. This regulation is due to a combination of specific lipid-protein interactions and more general lipid bilayer-protein interactions. These interactions are particularly important in pharmacological research, as many current pharmaceuticals on the market can alter the lipid bilayer material properties, which can lead to altered membrane protein function. The formation of gramicidin channels are dependent on conformational changes in gramicidin subunits which are in turn dependent on the properties of the lipid. Hence the gramicidin channel current is a reporter of altered properties of the bilayer due to certain compounds. © 2008 Journal of Visualized Experiments.

publication date

  • November 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2954507

Digital Object Identifier (DOI)

  • 10.3791/1032

PubMed ID

  • 19066527

Additional Document Info

number

  • 21