Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 Academic Article uri icon

Overview

MeSH Major

  • Alleles
  • Breast Neoplasms
  • Genes, BRCA1
  • Genes, BRCA2
  • Genetic Predisposition to Disease
  • Heterozygote
  • Mutation

abstract

  • The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers.

authors

publication date

  • November 2, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3326552

Digital Object Identifier (DOI)

  • 10.1186/bcr3052

PubMed ID

  • 22053997

Additional Document Info

start page

  • R110

volume

  • 13

number

  • 6