Kidney tubular toxicity of maintenance pemetrexed therapy Academic Article uri icon

Overview

MeSH Major

  • Antimetabolites, Antineoplastic
  • Glutamates
  • Guanine
  • Kidney Diseases
  • Kidney Tubules

abstract

  • Pemetrexed is an antifolate agent approved for the treatment of advanced lung cancer. Major side effects include myelosuppression and neutropenia. Three patients developed kidney disease while being treated with maintenance pemetrexed. Kidney biopsy specimens showed tubulointerstitial injury with tubular simplification, shrinkage, loss of brush border, and tubular atrophy in a more advanced case. Kidney function remained impaired, but stable, after discontinuation of pemetrexed therapy in all cases.

publication date

  • November 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1053/j.ajkd.2011.04.030

PubMed ID

  • 21849225

Additional Document Info

start page

  • 817

end page

  • 20

volume

  • 58

number

  • 5