Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury
Muscle, Smooth, Vascular
Nod2 Signaling Adaptor Protein
Functional NOD2 was found to be expressed in VSMCs, and NOD2 deficiency promoted VSMCs proliferation, migration, and neointimal formation after vascular injury. These results provide evidence for the involvement of NOD2 in vascular homeostasis and tissue injury, serving as a potential molecular target in the modulation of arteriosclerotic vascular disease.