Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury Academic Article uri icon

Overview

MeSH Major

  • Femoral Artery
  • Muscle, Smooth, Vascular
  • Neointima
  • Nod2 Signaling Adaptor Protein

abstract

  • Functional NOD2 was found to be expressed in VSMCs, and NOD2 deficiency promoted VSMCs proliferation, migration, and neointimal formation after vascular injury. These results provide evidence for the involvement of NOD2 in vascular homeostasis and tissue injury, serving as a potential molecular target in the modulation of arteriosclerotic vascular disease.

publication date

  • November 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3213020

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.111.235135

PubMed ID

  • 21903945

Additional Document Info

start page

  • 2441

end page

  • 7

volume

  • 31

number

  • 11