Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis. Academic Article uri icon

Overview

MeSH

  • Microbial Sensitivity Tests

MeSH Major

  • Anti-Bacterial Agents
  • Mycobacterium tuberculosis
  • Polyketides
  • Siderophores
  • Yersinia pestis

abstract

  • Mycobacterium tuberculosis (Mtb) and Yersinia pestis (Yp) produce siderophores with scaffolds of nonribosomal peptide-polyketide origin. Compounds with structural similarities to these siderophores were synthesized and evaluated as antimicrobials against Mtb and Yp under iron-limiting conditions mimicking the iron scarcity these pathogens encounter in the host and under standard iron-rich conditions. Several new antimicrobials were identified, including some with increased potency in the iron-limiting condition. Our study illustrates the possibility of screening compound libraries in both iron-rich and iron-limiting conditions to identify antimicrobials that may selectively target iron scarcity-adapted bacteria and highlights the usefulness of building combinatorial libraries of compounds having scaffolds with structural similarities to siderophores to feed into antimicrobial screening programs. Published by Elsevier Ltd.

publication date

  • November 1, 2011

has subject area

  • Anti-Bacterial Agents
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis
  • Polyketides
  • Siderophores
  • Yersinia pestis

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3210511

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2011.08.052

PubMed ID

  • 21940166

Additional Document Info

start page

  • 6533

end page

  • 6537

volume

  • 21

number

  • 21