Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis Academic Article uri icon

Overview

MeSH Major

  • Anti-Bacterial Agents
  • Mycobacterium tuberculosis
  • Polyketides
  • Siderophores
  • Yersinia pestis

abstract

  • Mycobacterium tuberculosis (Mtb) and Yersinia pestis (Yp) produce siderophores with scaffolds of nonribosomal peptide-polyketide origin. Compounds with structural similarities to these siderophores were synthesized and evaluated as antimicrobials against Mtb and Yp under iron-limiting conditions mimicking the iron scarcity these pathogens encounter in the host and under standard iron-rich conditions. Several new antimicrobials were identified, including some with increased potency in the iron-limiting condition. Our study illustrates the possibility of screening compound libraries in both iron-rich and iron-limiting conditions to identify antimicrobials that may selectively target iron scarcity-adapted bacteria and highlights the usefulness of building combinatorial libraries of compounds having scaffolds with structural similarities to siderophores to feed into antimicrobial screening programs.

publication date

  • November 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3210511

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2011.08.052

PubMed ID

  • 21940166

Additional Document Info

start page

  • 6533

end page

  • 7

volume

  • 21

number

  • 21