Drug discontinuation effects are part of the pharmacology of a drug Article uri icon


MeSH Major

  • Cardiovascular Agents
  • Drug-Related Side Effects and Adverse Reactions
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Substance Withdrawal Syndrome


  • Most reviews of drug withdrawal effects focus on drugs of potential abuse such as opioids, benzodiazepines, etc. Abrupt discontinuation of many other drugs used in medicine cause withdrawal syndromes, some of which can be fatal. Discontinuation of a number of cardiovascular drugs can increase risk of cardiovascular events above that of people not taking these drugs. These include β-adrenergic receptor antagonists, aspirin, HMG-CoA reductase inhibitors (statins), and heparin. Rebound hypertension occurs after abrupt cessation of many antihypertensive drugs. The possibility of discontinuation syndromes has usually been neglected until adverse clinical events force them to be noticed. Attention to the possibility of drug discontinuation effects is an important part of drug safety evaluation.

publication date

  • November 2011



  • Article



  • eng

PubMed Central ID

  • PMC3200000

Digital Object Identifier (DOI)

  • 10.1124/jpet.111.183285

PubMed ID

  • 21849624

Additional Document Info

start page

  • 324

end page

  • 8


  • 339


  • 2