The Spliceosome as an Indicted Conspirator in Myeloid Malignancies
Gene Expression Profiling
Leukemia, Myelomonocytic, Chronic
Reports of whole-exome sequencing in myelodysplastic syndrome (MDS) patients by Yoshida et al. and Papaemmanuil et al. suggest spliceosome mutations have clinical relevance. Identifying the impact of these mutations on MDS pathogenesis holds promise for therapeutic modulation of mRNA splicing.