The Spliceosome as an Indicted Conspirator in Myeloid Malignancies Article uri icon

Overview

MeSH Major

  • Gene Expression Profiling
  • Leukemia, Myelomonocytic, Chronic
  • Mutation
  • Neoplasm Proteins
  • Repressor Proteins

abstract

  • Reports of whole-exome sequencing in myelodysplastic syndrome (MDS) patients by Yoshida et al. and Papaemmanuil et al. suggest spliceosome mutations have clinical relevance. Identifying the impact of these mutations on MDS pathogenesis holds promise for therapeutic modulation of mRNA splicing.

publication date

  • October 18, 2011

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2011.10.004

Additional Document Info

start page

  • 420

end page

  • 3

volume

  • 20

number

  • 4