Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy Academic Article uri icon

Overview

MeSH Major

  • Benzodiazepines
  • Drug Resistance, Neoplasm
  • Leukemia, Myeloid, Acute
  • Neoplastic Stem Cells
  • Nuclear Proteins
  • Transcription Factors

abstract

  • In the recent years, the discovery of a series of mutations in patients with myeloid malignancies has provided insight into the pathogenesis of myelodysplastic syndromes (MDSs), myeloproliferative neoplasms (MPNs), and acute myeloid leukemia (AML). Among these alterations have been mutations in genes, such as IDH1/2, TET2, DNMT3A, and EZH2, which appear to affect DNA and/or histone lysine methylation. Large clinical correlative studies are beginning to decipher the clinical importance, prevalence, and potential prognostic significance of these mutations. Additionally, burgeoning insight into the role of epigenetics in the pathogenesis of myeloid malignancies has prompted increased interest in development of novel therapies which target DNA and histone posttranslational modifications. DNA demethylating agents have been demonstrated to be clinically active in a subset of patients with MDS and AML and are used extensively. However, newer, more specific agents which alter DNA and histone modification are under preclinical study and development and are likely to expand our therapeutic options for these diseases in the near future. Here, we review the current understanding of the clinical importance of these newly discovered mutations in AML and MDS patients. We also discuss exciting developments in DNA methyltransferase inhibitor strategies and the prospect of novel histone lysine methyltransferase inhibitors.

publication date

  • January 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3145345

Digital Object Identifier (DOI)

  • 10.1155/2012/469592

PubMed ID

  • 21811504

Additional Document Info

start page

  • 469592

volume

  • 2012