Anti-nuclear antibody positivity and the use of certolizumab in inflammatory bowel disease patients who have had arthralgias or lupus-like reactions from infliximab or adalimumab
Antibodies, Monoclonal, Humanized
Immunoglobulin Fab Fragments
Inflammatory Bowel Diseases
Lupus Erythematosus, Systemic
Tumor Necrosis Factor-alpha
Nearly all patients experienced relief from their lupus-like symptoms with certolizumab and 2 out of 4 patients reversed their ANA positivity. While future investigation is warranted, patients who have lupus-like reactions from infliximab or adalimumab may benefit from switching to certolizumab.