Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes Academic Article uri icon

Overview

MeSH Major

  • Diabetes Mellitus, Type 2
  • Fasting
  • Genome, Human
  • Polymorphism, Single Nucleotide
  • Proinsulin

abstract

  • We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis.

authors

publication date

  • October 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3178302

Digital Object Identifier (DOI)

  • 10.2337/db11-0415

PubMed ID

  • 21873549

Additional Document Info

start page

  • 2624

end page

  • 34

volume

  • 60

number

  • 10