Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties Academic Article uri icon

Overview

MeSH Major

  • Catechin
  • Ion Channel Gating
  • Ion Channels
  • Lipid Bilayers

abstract

  • Green tea's health benefits have been attributed to its major polyphenols, the catechins: (-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate (ECG), (-)-epigallocatechin (EGC), and epicatechin (EC). Catechins (especially EGCG) modulate a wide range of biologically important molecules, including many membrane proteins. Yet, little is known about their mechanism(s) of action. We tested the catechins' bilayer-modifying potency using gramicidin A (gA) channels as molecular force probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency (EGCG>ECG≫EGC>EC). Additionally, the gallate group causes current block, as evident by brief downward current transitions (flickers).

publication date

  • October 3, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3188397

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2011.08.040

PubMed ID

  • 21896274

Additional Document Info

start page

  • 3101

end page

  • 5

volume

  • 585

number

  • 19