Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma Academic Article uri icon

Overview

MeSH Major

  • Adenoviridae
  • Brain Neoplasms
  • Cancer Vaccines
  • Glioma
  • Immunotherapy
  • Thymidine Kinase

abstract

  • AdV-tk plus valacyclovir can be safely delivered with surgery and accelerated radiation in newly diagnosed malignant gliomas. Temozolomide did not prevent immune responses. Although not powered for efficacy, the survival and MGMT independence trends are encouraging. A phase II trial is ongoing.

publication date

  • September 20, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3179270

Digital Object Identifier (DOI)

  • 10.1200/JCO.2011.35.5222

PubMed ID

  • 21844505

Additional Document Info

start page

  • 3611

end page

  • 9

volume

  • 29

number

  • 27