Dual-Mode IVUS Transducer for Image-Guided Brain Therapy: Preliminary Experiments Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Glioblastoma
  • Hyperthermia, Induced
  • Surgery, Computer-Assisted
  • Transducers
  • Ultrasonography, Interventional

abstract

  • In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5-Fr IVUS catheter with a 5 × 0.5 × 0.22 mm PZT-4 transducer for 9-MHz imaging and (2) testing an identical transducer for therapy potential with 3.3-MHz continuous-wave excitation. The imaging transducer was compared with a 9-Fr, 9-MHz ICE catheter when visualizing the post-mortem ovine brain and was also used to attempt vascular access to an in vivo porcine brain. A net average electrical power input of 700 mW was applied to the therapy transducer, producing a temperature rise of +13.5°C at a depth of 1.5 mm in live brain tumor tissue in the mouse model. These results suggest that it may be feasible to combine the imaging and therapeutic capabilities into a single device as a clinically-viable instrument.

publication date

  • October 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3177008

Digital Object Identifier (DOI)

  • 10.1016/j.ultrasmedbio.2011.06.017

PubMed ID

  • 21856073

Additional Document Info

start page

  • 1667

end page

  • 76

volume

  • 37

number

  • 10