Stereoselective synthesis of F-ring saturated estrone-derived inhibitors of hedgehog signaling based on cyclopamine Academic Article uri icon

Overview

MeSH Major

  • Estrone
  • Hedgehog Proteins
  • Signal Transduction
  • Veratrum Alkaloids

abstract

  • Previous work in this laboratory established that the readily available F-ring aromatic analog of cyclopamine is a highly potent inhibitor of Hedgehog signaling. The synthesis and biological evaluation of two F-ring saturated analogs that are more potent than the F-ring aromatic structure are reported.

publication date

  • September 16, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3170508

Digital Object Identifier (DOI)

  • 10.1021/ol2017966

PubMed ID

  • 21842835

Additional Document Info

start page

  • 4786

end page

  • 9

volume

  • 13

number

  • 18