Imputation of incident events in longitudinal cohort studies Academic Article uri icon


MeSH Major

  • Bias (Epidemiology)
  • Continental Population Groups
  • Medical Records
  • Stroke


  • Longitudinal cohort studies normally identify and adjudicate incident events detected during follow-up by retrieving medical records. There are several reasons why the adjudication process may not be successfully completed for a suspected event including the inability to retrieve medical records from hospitals and an insufficient time between the suspected event and data analysis. These "incomplete adjudications" are normally assumed not to be events, an approach which may be associated with loss of precision and introduction of bias. In this article, the authors evaluate the use of multiple imputation methods designed to include incomplete adjudications in analysis. Using data from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study, 2008-2009, they demonstrate that this approach may increase precision and reduce bias in estimates of the relations between risk factors and incident events.

publication date

  • September 15, 2011



  • Academic Article



  • eng

PubMed Central ID

  • PMC3166710

Digital Object Identifier (DOI)

  • 10.1093/aje/kwr155

PubMed ID

  • 21804050

Additional Document Info

start page

  • 718

end page

  • 26


  • 174


  • 6