Tumor engraftment in nude mice and enrichment in stroma-related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Pancreatic Ductal
  • Deoxycytidine
  • Pancreatic Neoplasms
  • Smad4 Protein

abstract

  • A successful xenograft was generated in 61% of patients attempted, generating a pool of 42 PDA xenografts with significant biological information and annotated clinical data. Patients with PDA and SMAD4 inactivation have a better engraftment rate. Engraftment is a poor prognosis factor, and engrafted tumors have a metastatic gene expression signature. Tumors from gemcitabine-resistant patients were enriched in stromal pathways.

publication date

  • September 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3210576

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-11-0341

PubMed ID

  • 21742805

Additional Document Info

start page

  • 5793

end page

  • 800

volume

  • 17

number

  • 17