Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American Heart Association/American Stroke Association Review uri icon

Overview

MeSH Major

  • Alzheimer Disease
  • Cerebral Angiography
  • Mental Disorders

abstract

  • Vascular contributions to cognitive impairment and dementia are important. Understanding of VCI has evolved substantially in recent years, based on preclinical, neuropathologic, neuroimaging, physiological, and epidemiological studies. Transdisciplinary, translational, and transactional approaches are recommended to further our understanding of this entity and to better characterize its neuropsychological profile. There is a need for prospective, quantitative, clinical-pathological-neuroimaging studies to improve knowledge of the pathological basis of neuroimaging change and the complex interplay between vascular and Alzheimer disease pathologies in the evolution of clinical VCI and Alzheimer disease. Long-term vascular risk marker interventional studies beginning as early as midlife may be required to prevent or postpone the onset of VCI and Alzheimer disease. Studies of intensive reduction of vascular risk factors in high-risk groups are another important avenue of research.

publication date

  • September 2011

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3778669

Digital Object Identifier (DOI)

  • 10.1161/STR.0b013e3182299496

PubMed ID

  • 21778438

Additional Document Info

start page

  • 2672

end page

  • 713

volume

  • 42

number

  • 9