Impact of apolipoprotein ε4-cerebrospinal fluid beta-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment Academic Article uri icon

Overview

MeSH Major

  • Amyloid beta-Peptides
  • Apolipoprotein E4
  • Cognitive Dysfunction
  • Hippocampus

abstract

  • Baseline CSF Aβ predicts progression of hippocampal volume loss. APOE ɛ4 carrier status amplifies the degree of neurodegeneration in MCI. Understanding the effect of interactions between genetic risk and amyloid pathology will be important in clinical trials and our understanding of the disease process.

publication date

  • September 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3177162

Digital Object Identifier (DOI)

  • 10.1016/j.jalz.2010.12.010

PubMed ID

  • 21889115

Additional Document Info

start page

  • 514

end page

  • 20

volume

  • 7

number

  • 5