TET family proteins and their role in stem cell differentiation and transformation Review uri icon

Overview

MeSH Major

  • Cell Differentiation
  • DNA-Binding Proteins
  • Hematologic Neoplasms
  • Myeloid Cells
  • Proto-Oncogene Proteins
  • Stem Cells

abstract

  • One of the main regulators of gene expression during embryogenesis and stem cell differentiation is DNA methylation. The recent identification of hydroxymethylcytosine (5hmC) as a novel epigenetic mark sparked an intense effort to characterize its specialized enzymatic machinery and to understand the biological significance of 5hmC. The recent discovery of recurrent deletions and somatic mutations in the TET gene family, which includes proteins that can hydroxylate methylcytosine (5mC), in a large fraction of myeloid malignancies further suggested a key role for dynamic DNA methylation changes in the regulation of stem cell differentiation and transformation.

publication date

  • September 2, 2011

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3244690

Digital Object Identifier (DOI)

  • 10.1016/j.stem.2011.08.007

PubMed ID

  • 21885017

Additional Document Info

start page

  • 193

end page

  • 204

volume

  • 9

number

  • 3