Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response Academic Article uri icon

Overview

MeSH Major

  • Dermatitis, Atopic
  • Ultraviolet Therapy

abstract

  • Our study shows that resolution of clinical disease in patients with chronic AD is accompanied by reversal of both the epidermal defects and the underlying immune activation. We have defined a set of biomarkers of disease response that associate resolved T(H)2 and T22 inflammation in patients with chronic AD with reversal of barrier pathology. By showing reversal of the AD epidermal phenotype with a broad immune-targeted therapy, our data argue against a fixed genetic phenotype.

publication date

  • September 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3448950

Digital Object Identifier (DOI)

  • 10.1016/j.jaci.2011.05.042

PubMed ID

  • 21762976

Additional Document Info

start page

  • 583

end page

  • 93.e1-4

volume

  • 128

number

  • 3