Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images. Academic Article uri icon


MeSH Major

  • Algorithms
  • Cornea
  • Diabetic Retinopathy
  • Image Interpretation, Computer-Assisted
  • Microscopy, Confocal
  • Nerve Fibers
  • Ophthalmoscopy
  • Pattern Recognition, Automated


  • Corneal Confocal Microscopy (CCM) imaging is a non-invasive surrogate of detecting, quantifying and monitoring diabetic peripheral neuropathy. This paper presents an automated method for detecting nerve-fibres from CCM images using a dual-model detection algorithm and compares the performance to well-established texture and feature detection methods. The algorithm comprises two separate models, one for the background and another for the foreground (nerve-fibres), which work interactively. Our evaluation shows significant improvement (p approximately 0) in both error rate and signal-to-noise ratio of this model over the competitor methods. The automatic method is also evaluated in comparison with manual ground truth analysis in assessing diabetic neuropathy on the basis of nerve-fibre length, and shows a strong correlation (r = 0.92). Both analyses significantly separate diabetic patients from control subjects (p approximately 0).

publication date

  • November 18, 2010



  • Academic Article



  • eng

PubMed Central ID

  • PMC3066470

PubMed ID

  • 20879244

Additional Document Info

start page

  • 300

end page

  • 7


  • 13


  • Pt 1