Farnesyl transferase expression determines clinical response to the docetaxel-lonafarnib combination in patients with advanced malignancies Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Farnesyltranstransferase
  • Neoplasms
  • Piperidines
  • Pyridines
  • Taxoids

abstract

  • Despite the small number of patients, these findings support our preclinical mechanistic studies and warrant further clinical investigations using FTase-beta mRNA expression as a potential predictive biomarker to select for an enriched patient population to study the effects of taxane and FTase inhibitor combination therapies.

publication date

  • September 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3131496

Digital Object Identifier (DOI)

  • 10.1002/cncr.26004

PubMed ID

  • 21365629

Additional Document Info

start page

  • 4049

end page

  • 59

volume

  • 117

number

  • 17