Prognostic immune markers in non-small cell lung cancer Review uri icon


MeSH Major

  • Biomarkers, Tumor
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms
  • Tumor Microenvironment


  • Tumor-associated immune responses have polarized effects in regulating tumor growth. Although a clear association has been shown between the tumor immune response and clinical outcome in colorectal and ovarian cancers, the role of immune markers for stratifying prognosis in non-small cell lung cancer (NSCLC) is less defined. Herein, we review the prognostic significance of published immune markers in the tumor microenvironment and peripheral blood of NSCLC patients. To identify prognostic immune genes, we reviewed all published gene-profiling studies in NSCLC and delineated the significance of immune genes by doing subanalysis on the microarray database of the NIH Director's Challenge study. This first comprehensive review of prognostic immune markers provides a foundation for further investigating immune responses in NSCLC.

publication date

  • August 15, 2011



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-10-2805

PubMed ID

  • 21659461

Additional Document Info

start page

  • 5247

end page

  • 56


  • 17


  • 16