Plerixafor plus granulocyte-colony stimulating factor for autologous hematopoietic stem cell mobilization in patients with metastatic neuroblastoma Academic Article uri icon

Overview

MeSH Major

  • Granulocyte Colony-Stimulating Factor
  • Hematopoietic Stem Cell Mobilization
  • Heterocyclic Compounds
  • Neuroblastoma
  • Receptors, CXCR4

abstract

  • Current therapies for high-risk neuroblastoma (NB) necessitate the availability of several aliquots of autologous peripheral blood stem cells to reverse-associated myelosuppression. Priming with the CXCR4 inhibitor plerixafor plus G-CSF was associated with successful stem cell harvest in 5/7 heavily prior-treated patients with stage 4 NB who had previously failed G-CSF priming. Minimal residual disease was not detected in harvested cells from any patient despite the presence of disease in bone/bone marrow in 6/7. Hematopoietic reconstitution was achieved in all three patients receiving plerixafor-primed stem cells after myeloablative therapy. Plerixafor is an effective and safe agent for stem cell collection in patients with NB.

publication date

  • March 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/pbc.23132

PubMed ID

  • 21416584

Additional Document Info

start page

  • 469

end page

  • 71

volume

  • 58

number

  • 3