Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma Academic Article uri icon

Overview

MeSH Major

  • Chromosomes, Human, Pair 6
  • Gene Expression Regulation, Neoplastic
  • Hodgkin Disease
  • Mutation
  • Neoplasms, Second Primary
  • Radiotherapy
  • Repressor Proteins

abstract

  • Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy-induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodgkin's lymphoma treated with radiation therapy as children but not as adults. The variants comprise a risk locus associated with decreased basal expression of PRDM1 (encoding PR domain containing 1, with ZNF domain) and impaired induction of the PRDM1 protein after radiation exposure. These data suggest a new gene-exposure interaction that may implicate PRDM1 in the etiology of radiation therapy-induced SMNs.

publication date

  • August 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3229923

Digital Object Identifier (DOI)

  • 10.1038/nm.2407

PubMed ID

  • 21785431

Additional Document Info

start page

  • 941

end page

  • 3

volume

  • 17

number

  • 8