Mitotic catastrophe: a mechanism for avoiding genomic instability. Review uri icon

Overview

MeSH Major

  • Aneuploidy
  • Chromosome Aberrations
  • Genomic Instability
  • Mitosis
  • Spindle Apparatus

abstract

  • The improper distribution of chromosomes during mitosis compromises cellular functions and can reduce cellular fitness or contribute to malignant transformation. As a countermeasure, higher eukaryotes have developed strategies for eliminating mitosis-incompetent cells, one of which is mitotic catastrophe. Mitotic catastrophe is driven by a complex and poorly understood signalling cascade but, from a functional perspective, it can be defined as an oncosuppressive mechanism that precedes (and is distinct from) apoptosis, necrosis or senescence. Accordingly, the disruption of mitotic catastrophe precipitates tumorigenesis and cancer progression, and its induction constitutes a therapeutic endpoint.

publication date

  • June 2011

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nrm3115

PubMed ID

  • 21527953

Additional Document Info

start page

  • 385

end page

  • 92

volume

  • 12

number

  • 6