Biologic phenotyping of the human small airway epithelial response to cigarette smoking
Gene Expression Profiling
Gene Expression Regulation
Pulmonary Disease, Chronic Obstructive
The SAE transcriptome can be used to classify clinically healthy smokers into subgroups with lesser and greater responses to cigarette smoking, even though these subgroups are indistinguishable by clinical criteria. This identifies a group of smokers with a "COPD-like" SAE transcriptome.