Advances in sarcoma genomics and new therapeutic targets Review uri icon

Overview

MeSH Major

  • Genomics
  • Sarcoma

abstract

  • Increasingly, human mesenchymal malignancies are being classified by the abnormalities that drive their pathogenesis. Although many of these aberrations are highly prevalent within particular sarcoma subtypes, few are currently targeted therapeutically. Indeed, most subtypes of sarcoma are still treated with traditional therapeutic modalities, and in many cases sarcomas are resistant to adjuvant therapies. In this Review, we discuss the core molecular determinants of sarcomagenesis and emphasize the emerging genomic and functional genetic approaches that, coupled with novel therapeutic strategies, have the potential to transform the care of patients with sarcoma.

publication date

  • August 2011

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3361898

Digital Object Identifier (DOI)

  • 10.1038/nrc3087

PubMed ID

  • 21753790

Additional Document Info

start page

  • 541

end page

  • 57

volume

  • 11

number

  • 8