An integrative view of mechanisms underlying generalized Apike-And-Wave epileptic seizures and its implication on optimal therapeutic treatments Academic Article uri icon

Overview

MeSH Major

  • Action Potentials
  • Epilepsy

abstract

  • Many types of epileptic seizures are characterized by generalized spike-and-wave discharges. In the past, notable effort has been devoted to understanding seizure dynamics and various hypotheses have been proposed to explain the underlying mechanisms. In this paper, by taking an integrative view of the underlying mechanisms, we demonstrate that epileptic seizures can be generated by many different combinations of synaptic strengths and intrinsic membrane properties. This integrative view has important medical implications: the specific state of a patient characterized by a set of biophysical characteristics ultimately determines the optimal therapeutic treatment. Through the same view, we further demonstrate the potentiation effect of rational polypharmacy in the treatment of epilepsy and provide a new angle to resolve the debate on polypharmacy. Our results underscore the need for personalized medicine and demonstrate that computer modeling and simulation may play an important role in assisting the clinicians in selecting the optimal treatment on an individual basis.

publication date

  • July 27, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3141053

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0022440

PubMed ID

  • 21811612

Additional Document Info

start page

  • e22440

volume

  • 6

number

  • 7