Proteome analysis of host-pathogen interactions: Investigation of pathogen responses to the host cell environment Article Report uri icon

Overview

MeSH Major

  • Cell Transformation, Viral
  • Oncogenes
  • Receptors, Cell Surface

abstract

  • Infectious diseases are still a major health risk, and thus a better understanding of the interaction between human host cells and pathogenic microbes is urgently required. Since the interplay between both partners is highly complex, genome-wide analysis by OMICs approaches will likely make a major contribution to the elucidation of the pathophysiology of infection processes. In the concert of OMICs technologies, proteomics is particularly important because it reveals changes in the active players of the cell and has thus a close relationship to the phenotypic changes observed. While proteomic studies of in vitro-grown microbial pathogens are routinely established in many labs, in vivo proteomic approaches are still rare. Here, we will review the challenges and recent developments of proteomic analysis of microbial pathogens derived from cell culture or in vivo infection settings and summarize some lessons that have been learned from these studies. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

publication date

  • August 15, 2011

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1002/pmic.201100158

PubMed ID

  • 21710565

Additional Document Info

start page

  • 3203

end page

  • 3211

volume

  • 11

number

  • 15