MTOR inhibitors in advanced renal cell carcinoma Review uri icon

Overview

MeSH Major

  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Protein Kinase Inhibitors
  • TOR Serine-Threonine Kinases

abstract

  • Better understanding of the molecular biology of renal cell carcinoma (RCC) has led to the development of several targeted anti-cancer agents, several of which have since received approval for treatment of advanced disease. Two of these, the intravenous agent temsirolimus and the oral everolimus, exhibit antitumor effects through inhibition of the mammalian target of rapamycin (mTOR) pathway. This article reviews their mechanisms of action in the context of the current understanding of RCC pathophysiology, the clinical data leading to their approval, class-specific toxicities, potential molecular mechanisms behind treatment resistance and novel treatment approaches for RCC that incorporate mTOR blockade.

publication date

  • August 2011

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3587783

Digital Object Identifier (DOI)

  • 10.1016/j.hoc.2011.04.008

PubMed ID

  • 21763970

Additional Document Info

start page

  • 835

end page

  • 52

volume

  • 25

number

  • 4