Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation Academic Article uri icon

Overview

MeSH Major

  • Bone Marrow Transplantation
  • Carcinoembryonic Antigen
  • Graft vs Host Disease
  • Graft vs Tumor Effect

abstract

  • We conclude that Ceacam1 regulates T cell activation, GVHD target organ damage, and numbers of donor T cells in lymphoid organs and GVHD target tissues. In recipients of allo-BMT, Ceacam1 may also regulate tissue radiosensitivity. Because of its expression on both the donor graft and host tissues, this suggests that targeting Ceacam1 may represent a potent strategy for the regulation of GVHD and GVT after allogeneic transplantation.

publication date

  • July 11, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3130781

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0021611

PubMed ID

  • 21760897

Additional Document Info

start page

  • e21611

volume

  • 6

number

  • 7