Relationship between labile plasma iron, liver iron concentration and cardiac response in a deferasirox monotherapy trial Academic Article uri icon

Overview

MeSH Major

  • Benzoates
  • Heart
  • Iron
  • Iron Chelating Agents
  • Iron Overload
  • Liver
  • Myocardium
  • Triazoles

abstract

  • The US04 trial was a multicenter, open-label, single arm trial of deferasirox monotherapy (30-40 mg/kg/day) for 18 months. Cardiac iron response was bimodal with improvements observed in patients with mild to moderate initial somatic iron stores; relationship of cardiac response to labile plasma iron is now presented. Labile plasma iron was measured at baseline, six months, and 12 months. In patients having a favorable cardiac response at 18 months, initial labile plasma iron was elevated in only 31% of patients at baseline and no patient at six or 12 months. Cardiac non-responders had elevated labile plasma iron in 50% of patients at baseline, 50% patients at six months, and 38% of patients at 12 months. Risk of abnormal labile plasma iron and cardiac response increased with initial liver iron concentration. Persistently increased labile plasma iron predicts cardiac non-response to deferasirox but labile plasma iron suppression does not guarantee favorable cardiac outcome. Study registered at www.clinicaltrials.gov (NCT00447694).

publication date

  • July 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3128226

Digital Object Identifier (DOI)

  • 10.3324/haematol.2010.032862

PubMed ID

  • 21393329

Additional Document Info

start page

  • 1055

end page

  • 8

volume

  • 96

number

  • 7